Positive Technology Journal

Effects of meditation on frontal alpha-asymmetry in previously suicidal individuals.

Neuroreport. 2007 May 7;18(7):709-12

Authors: Barnhofer T, Duggan D, Crane C, Hepburn S, Fennell MJ, Williams JM

This study investigated the effects of a meditation-based treatment for preventing relapse to depression, mindfulness-based cognitive therapy (MBCT), on prefrontal alpha-asymmetry in resting electroencephalogram (EEG), a biological indicator of affective style. Twenty-two individuals with a previous history of suicidal depression were randomly assigned to either MBCT (N=10) or treatment-as-usual (TAU, N=12). Resting electroencephalogram was measured before and after an 8-week course of treatment. The TAU group showed a significant deterioration toward decreased relative left-frontal activation, indexing decreases in positive affective style, while there was no significant change in the MBCT group. The findings suggest that MBCT can help individuals at high risk for suicidal depression to retain a balanced pattern of baseline emotion-related brain activation.

The role of thought suppression in the relationship between mindfulness meditation and alcohol use.

Addict Behav. 2007 Jan 23;

Authors: Bowen S, Witkiewitz K, Dillworth TM, Marlatt GA

Previous studies have demonstrated that attempts to suppress thoughts about using substances may actually lead to increases in substance use. Vipassana, a mindfulness meditation practice, emphasizes acceptance, rather than suppression, of unwanted thoughts. A study by Bowen and colleagues examining the effects of a Vipassana course on substance use in an incarcerated population showed significant reductions in substance use among the Vipassana group as compared to a treatment - usual control condition [Bowen S., Witkiewitz K., Dillworth T.M., Chawla N., Simpson T.L., Ostafin B.D., et al. (2006). Mindfulness Meditation and Substance Use in an Incarcerated Population. Psychology of Addictive Behaviors.]. The current study further examines the mediating effects of thought suppression in the relationship between participation in the course and subsequent alcohol use. Those who participated in the course reported significant decreases in avoidance of thoughts when compared to controls. The decrease in avoidance partially mediated effects of the course on post-release alcohol use and consequences.

Studies of chinese original quiet sitting by using functional magnetic resonance imaging.

Conf Proc IEEE Eng Med Biol Soc. 2005;5:5317-9

Authors: Liou CH, Hsieh CW, Hsieh CH, Chen JH, Wang CH, Lee SC

Since different meditations may activate different regions in brain, we can use functional magnetic resonance imaging (fMRI) to investigate it. Chinese original quiet sitting is mainly one kind of traditional Chinese meditation. It contains two different parts: a short period of keeping phrase and intake spiritual energy, and a long period of relaxation with no further action. In this paper, both those two stages were studied by fMRI. We performed two different paradigms and found the accurate positions in the brain. The pineal gland and the hypothalamus showed positive activation during the first and second stages of this meditation. The BOLD (Blood Oxygenation Level Dependent) signal changes had also been found.

The application of mindfulness-based cognitive interventions in the treatment of co-occurring addictive and mood disorders.

CNS Spectr. 2006 Nov;11(11):829-51

Authors: Hoppes K

This article reviews the theory, clinical application, and empirical findings on mindfulness-based cognitive therapy (MBCT) for mental health and addictive disorders. Expanding upon the research demonstrating the efficacy of cognitive-behavioral therapy (CBT) for addiction, this article develops and explores the rationale for combining mindfulness-based interventions with evidence-based CBTs in treating addictive disorders, with an emphasis on substance use disorders with co-occurring mood disorders. This article proposes that deficits in affect--regulation related to the behavioral and emotional effects of neurobiological changes that occur with long-term substance abuse--pose a unique set of challenges in early recovery. Prolonged use of addictive substances impairs the brain pathways that mediate certain affect regulation functions. These functions involve attention and inhibitory control, the saliency of and response to addictive versus natural reward stimuli, and the ability to detach or maintain perspective in response to strong emotional states. In treating this affective dysregulation, which can contribute to the vulnerability to relapse in the early stages of recovery, the affect-regulation-specific focus of MBCT adds a valuable element to augment CBT for addiction. Summarizing magnetic resonance imaging and positron emission tomography findings on the effects of MBCT and the neurobiology of drug addiction, this article outlines directions for further research on potential benefits of MBCT for the recovering individual. Finally, this article describes a structured protocol, developed at the Mount Sinai School of Medicine in New York City, which combines CBT with mindfulness-based intervention, for the treatment of affect-regulation issues specific to co-occurring addictive and mood disorders.

A randomized controlled trial of mindfulness meditation versus relaxation training: effects on distress, positive States of mind, rumination, and distraction.

Ann Behav Med. 2007 Feb;33(1):11-21

Authors: Jain S, Shapiro SL, Swanick S, Roesch SC, Mills PJ, Bell I, Schwartz GE

Background: Although mindfulness meditation interventions have recently shown benefits for reducing stress in various populations, little is known about their relative efficacy compared with relaxation interventions. Purpose: This randomized controlled trial examines the effects of a 1-month mindfulness meditation versus somatic relaxation training as compared to a control group in 83 students (M age = 25; 16 men and 67 women) reporting distress. Method: Psychological distress, positive states of mind, distractive and ruminative thoughts and behaviors, and spiritual experience were measured, while controlling for social desirability. Results: Hierarchical linear modeling reveals that both meditation and relaxation groups experienced significant decreases in distress as well as increases in positive mood states over time, compared with the control group (p < .05 in all cases). There were no significant differences between meditation and relaxation on distress and positive mood states over time. Effect sizes for distress were large for both meditation and relaxation (Cohen's d = 1.36 and .91, respectively), whereas the meditation group showed a larger effect size for positive states of mind than relaxation (Cohen's d =.71 and .25, respectively). The meditation group also demonstrated significant pre-post decreases in both distractive and ruminative thoughts/behaviors compared with the control group (p < .04 in all cases; Cohen's d = .57 for rumination and .25 for distraction for the meditation group), with mediation models suggesting that mindfulness meditation's effects on reducing distress were partially mediated by reducing rumination. No significant effects were found for spiritual experience. Conclusions: The data suggest that compared with a no-treatment control, brief training in mindfulness meditation or somatic relaxation reduces distress and improves positive mood states. However, mindfulness meditation may be specific in its ability to reduce distractive and ruminative thoughts and behaviors, and this ability may provide a unique mechanism by which mindfulness meditation reduces distress.

The role of thought suppression in the relationship between mindfulness meditation and alcohol use.

Addict Behav. 2007 Jan 23;

Authors: Bowen S, Witkiewitz K, Dillworth TM, Marlatt GA

Previous studies have demonstrated that attempts to suppress thoughts about using substances may actually lead to increases in substance use. Vipassana, a mindfulness meditation practice, emphasizes acceptance, rather than suppression, of unwanted thoughts. A study by Bowen and colleagues examining the effects of a Vipassana course on substance use in an incarcerated population showed significant reductions in substance use among the Vipassana group as compared to a treatment - usual control condition [Bowen S., Witkiewitz K., Dillworth T.M., Chawla N., Simpson T.L., Ostafin B.D., et al. (2006). Mindfulness Meditation and Substance Use in an Incarcerated Population. Psychology of Addictive Behaviors.]. The current study further examines the mediating effects of thought suppression in the relationship between participation in the course and subsequent alcohol use. Those who participated in the course reported significant decreases in avoidance of thoughts when compared to controls. The decrease in avoidance partially mediated effects of the course on post-release alcohol use and consequences.

Mindfulness meditation alleviates depressive symptoms in women with fibromyalgia: Results of a randomized clinical trial.

Arthritis Rheum. 2007 Jan 31;57(1):77-85

Authors: Sephton SE, Salmon P, Weissbecker I, Ulmer C, Floyd A, Hoover K, Studts JL

OBJECTIVE: Depressive symptoms are common among patients with fibromyalgia, and behavioral intervention has been recommended as a major treatment component for this illness. The objective of this study was to test the effects of the Mindfulness-Based Stress Reduction (MBSR) intervention on depressive symptoms in patients with fibromyalgia. METHODS: This randomized controlled trial examined effects of the 8-week MBSR intervention on depressive symptoms in 91 women with fibromyalgia who were randomly assigned to treatment (n = 51) or a waiting-list control group (n = 40). Eligible patients were at least 18 years old, willing to participate in a weekly group, and able to provide physician verification of a fibromyalgia diagnosis. Of 166 eligible participants who responded to local television news publicizing, 49 did not appear for a scheduled intake, 24 enrolled but did not provide baseline data, and 2 were excluded due to severe mental illness, leaving 91 participants. The sample averaged 48 years of age and had 14.7 years of education. The typical participant was white, married, and employed. Patients randomly assigned to treatment received MBSR. Eight weekly 2.5-hour sessions were led by a licensed clinical psychologist with mindfulness training. Somatic and cognitive symptoms of depression were assessed using the Beck Depression Inventory administered at baseline, immediately postprogram, and at followup 2 months after the conclusion of the intervention. RESULTS: Change in depressive symptoms was assessed using slopes analyses of intervention effects over time. Depressive symptoms improved significantly in treatment versus control participants over the 3 assessments. CONCLUSION: This meditation-based intervention alleviated depressive symptoms among patients with fibromyalgia.

A pilot study on mindfulness based stress reduction for smokers.

BMC Complement Altern Med. 2007 Jan 25;7(1):2

Authors: Davis JM, Fleming MF, Bonus KA, Baker TB

ABSTRACT: BACKGROUND: Mindfulness means paying attention in the present moment, non-judgmentally, without commentary or decision-making. We report results of a pilot study designed to test the feasibility of using Mindfulness Based Stress Reduction (MBSR) (with minor modifications) as a smoking intervention. METHODS: MBSR instructors provided instructions in mindfulness in eight weekly group sessions. Subjects attempted smoking cessation during week seven without pharmacotherapy. Smoking abstinence was tested six weeks after the smoking quit day with carbon monoxide breath test and 7-day smoking calendars. Questionnaires were administered to evaluate changes in stress and affective distress. RESULTS: 18 subjects enrolled in the intervention with an average smoking history of 19.9 cigarettes per day for 26.4 years. At the 6-week post-quit visit, 10 of 18 subjects (56%) achieved biologically confirmed 7-day point-prevalent smoking abstinence. Compliance with meditation was positively associated with smoking abstinence and decreases in stress and affective distress. CONCLUSIONS: The results of this study suggest that mindfulness training may show promise for smoking cessation and warrants additional study in a larger comparative trial.

Studies of advanced stages of meditation in the tibetan buddhist and vedic traditions. I: a comparison of general changes.

Evid Based Complement Alternat Med. 2006 Dec;3(4):513-21

Authors: Hankey A

This article is the first of two comparing findings of studies of advanced practitioners of Tibetan Buddhist meditation in remote regions of the Himalayas, with established results on long-term practitioners of the Transcendental Meditation programs. Many parallel levels of improvement were found, in sensory acuity, perceptual style and cognitive function, indicating stabilization of aspects of attentional awareness. Together with observed increases in EEG coherence and aspects of brain function, such changes are consistent with growth towards a state of total brain functioning, i.e. development of full mental potential. They are usually accompanied by improved health parameters. How they may be seen to be consistent with growth of enlightenment will be the subject of a second article.

Psychother Psychosom Med Psychol. 2006 Dec;56(12):488-492

Authors: Neumann NU, Frasch K

Meditation in general can be understood as a state of complete and unintentional silent and motionless concentration on an activity, an item or an idea. Subjectively, meditative experience is said to be fundamentally different from "normal" mental states and is characterized by terms like timelessness, boundlessness and lack of self-experience. In recent years, several fMRI- and PET-studies about meditation which are presented in this paper have been published. Due to different methods, especially different meditation types, the results are hardly comparable. Nevertheless, the data suggest the hypothesis of a "special" neural activity during meditative states being different from that during calm alertness. Main findings were increased activation in frontal, prefrontal and cingulate areas which may represent the mental state of altered self-experience. In the present studies, a considerable lack of scientific standards has to be stated making it of just casuistic value. Today's improved neurobiological examination methods - especially neuroimaging techniques - may contribute to enlighten the phenomenon of qualitatively different states of consciousness.

Changes in p300 following two yoga-based relaxation techniques.

Int J Neurosci. 2006 Dec;116(12):1419-30

Authors: Sarang SP, Telles S

Cyclic meditation (CM) is a technique that combines "stimulating" and "calming" practices, based on a statement in ancient yoga texts suggesting that such a combination may be especially helpful to reach a state of mental equilibrium. The changes in the peak latency and peak amplitude of P300 auditory event-related potentials were studied before and after the practice of cyclic meditation compared to an equal duration of supine rest in 42 volunteers (group mean age +/- SD, 27 +/- 6.3 years), from Fz, Cz, and Pz electrode sites referenced to linked earlobes. The sessions were one day apart and the order was alternated. There was reduction in the peak latencies of P300 after cyclic meditation at Fz, Cz, and Pz compared to the "pre" values. A similar trend of reduction in P300 peak latencies at Fz, Cz, and Pz was also observed after supine rest, compared to the respective "pre" values, although the magnitude of change in each case was less after supine rest compared to after cyclic meditation. The P300 peak amplitudes after CM were higher at Fz, Cz, and Pz sites compared to the "pre" values. In contrast, no significant changes were observed in the P300 peak amplitudes at Fz, Cz, and Pz after supine rest compared to the respective "pre" state. The present results support the idea that "cyclic" meditation enhances cognitive processes underlying the generation of the P300.

Cross-sectional and longitudinal study of effects of transcendental meditation practice on interhemispheric frontal asymmetry and frontal coherence.

Int J Neurosci. 2006 Dec;116(12):1519-38

Authors: Travis F, Arenander A

Two studies investigated frontal alpha lateral asymmetry and frontal interhemispheric coherence during eyes-closed rest, Transcendental Meditation (TM) practice, and computerized reaction-time tasks. In the first study, frontal coherence and lateralized asymmetry were higher in 13 TM subjects than in 12 controls. In the second study (N = 14), a one-year longitudinal study, lateral asymmetry did not change in any condition. In contrast, frontal coherence increased linearly during computer tasks and eyes-closed rest, and as a step-function during TM practice-rising to a high level after 2-months TM practice. Coherence was more sensitive than lateral asymmetry to effects of TM practice on brain functioning.

Tongue Piercing by a Yogi: QEEG Observations.

Appl Psychophysiol Biofeedback. 2006 Nov 3;

Authors: Peper E, Wilson VE, Gunkelman J, Kawakami M, Sata M, Barton W, Johnston J

This study reports on the QEEG observations recorded from a yogi during tongue piercing in which he demonstrated voluntary pain control. The QEEG was recorded with a Lexicor 1620 from 19 sites with appropriate controls for impedence and artifacts. A neurologist read the data for abnormalities and the QEEG was analyzed by mapping, single and multiple hertz bins, coherence, and statistical comparisons with a normative database. The session included a meditation baseline and tongue piercing. During the meditative baseline period the yogi's QEEG maps suggesting that he was able to lower his brain activity to a resting state. This state showed a predominance of slow wave potentials (delta) during piercing and suggested that the yogi induced a state that may be similar to those found when individuals are under analgesia. Further research should be conducted with a group of individuals who demonstrate exceptional self-regulation to determine the underlying mechanisms, and whether the skills can be used to teach others how to manage pain.

Via Mindware forum (by way of the LifeHacker blog)

Yoga Today offers daily yoga instruction videos that can be downloaded for free. The videos are shot against an awesome Wyoming landscape and delivered in the iHD format

Science and Consciousness Review has interviewed brain researcher Sara Lazar on how meditation affects the brain. Lazar is the author of a recent study, in which magnetic resonance imaging was used to assess cortical thickness in 20 participants with extensive Insight meditation, a technique that involves focusing attention on internal experiences. Findings showed that brain regions associated with attention, interoception and sensory processing were thicker in meditation participants than matched controls, including the prefrontal cortex and right anterior insula. According to Lazar and her colleagues, these results provide preliminary evidence for experience-dependent cortical plasticity associated with meditation practice.

Via Mind Hacks

Time has an interesting article about neuroscience of meditation. Taking advantage of advanced brain imaging techniques such as fMRI and PET, scholars are casting light on how the practice of meditation affects brain structure and its functions. Moreover, psychological research is collecting evidence that meditation can improve key cognitive capabilities such as attention and memory

From Molecular Biology to Anti-aging Cognitive-Behavioral Practices: The Pioneering Research of Walter Pierpaoli on the Pineal and Bone Marrow Foreshadows the Contemporary Revolution in Stem Cell and Regenerative Biology.

Ann N Y Acad Sci. 2005 Dec;1057:28-49

Authors: Bushell WC

Evidence is accruing that a cognitive-behavioral regimen integrating cognitive techniques (meditation-based anti-stress, anti-inflammatory techniques, others), dietary modification ("dietary restriction" or modified dietary restriction), and certain forms of aerobic exercise, may prolong the healthy life span in humans. Recent research has identified some of the likely molecular mediators of these potentially broad-ranging, health-enhancing and anti-aging effects; these include DHEA, interleukins -10 and -4 (IL-10, 1L-4), and especially melatonin. Relatedly, what some are calling a revolution in biology and medicine has been emerging from research on stem cells and regeneration processes more generally. Dogma regarding limitations on the regenerative capacities of adult vertebrates is being cautiously yet enthusiastically revised in the wake of rapidly accumulating discoveries of more types of adult stem cells in mammals, including humans. For example, a recent review by D. Krause of Yale concluded that "in the [adult] bone marrow, in addition to hematopoietic stem cells and supportive stromal cells, there are cells with the potential to differentiate into mature cells of the heart, liver, kidney, lungs, GI tract, skin, bone, muscle, cartilage, fat, endothelium and brain." In addition, very recent studies have shown that DHEA, ILs-10 and -4, and melatonin all possess potential regenerative, including stem cell-activating, properties. More than a quarter of a century ago, Walter Pierpaoli initiated a series of extraordinary studies that demonstrated in experimental animals the potential for dramatic regeneration associated with changes in the pineal gland and bone marrow. This appeared to be not only retardation of aging, but also its reversal. Furthermore, as Pierpaoli was attempting to understand both anti-aging regeneration and oncogenesis, he was focusing on both pro- and anti-mitotic mechanisms: recent research now suggests that there is a nonpathologic, "healthy" form of regeneration that is actually antagonistic to oncogenesis, and that melatonin may be important in this form of regeneration. This paper explores Pierpaoli's pioneering studies in light of recent developments in stem cell and regenerative biology, particularly as related to the regenerative potential associated with certain cognitive-behavioral practices, and includes evidence on this subject presented for the first time.

Via Neurodudes

A new experiments by Raz et al., recently published in the Proceedings of the National Academy of Science, found that hypnotic suggestion affects cognitive control by modulating activity in specific brain areas, namely visual areas and the anterior cingulate cortex, which is involved in conflict monitoring.

Abstract: Many studies have suggested that conflict monitoring involves the anterior cingulate cortex (ACC). We previously showed that a specific hypnotic suggestion reduces involuntary conflict and alters information processing in highly hypnotizable individuals. Hypothesizing that such conflict reduction would be associated with decreased ACC activation, we combined neuroimaging methods to provide high temporal and spatial resolution and studied highly and less-hypnotizable participants both with and without a suggestion to interpret visual words as nonsense strings. Functional MRI data revealed that under posthypnotic suggestion, both ACC and visual areas presented reduced activity in highly hypnotizable persons compared with either no-suggestion or less-hypnotizable controls. Scalp electrode recordings in highly hypnotizable subjects also showed reductions in posterior activation under suggestion, indicating visual system alterations. Our findings illuminate how suggestion affects cognitive control by modulating activity in specific brain areas, including early visual modules, and provide a more scientific account relating the neural effects of suggestion to placebo.

Via Mind Hacks

A new study published in the journal NeuroReport has found evidence that meditation alters brain patterns. The MRI experiment involved 20 participants with extensive Insight meditation experience. Most of the brain regions identified to be changed through meditation were found in the right hemisphere, which is essential for sustaining attention.

Lazar SW, Kerr CE, Wasserman RH, Gray JR, Greve DN, Treadway MT, McGarvey M, Quinn BT, Dusek JA, Benson H, Rauch SL, Moore CI, Fischl B., Meditation experience is associated with increased cortical thickness. Neuroreport. 2005 Nov 28;16(17):1893-1897.

Abstract. Previous research indicates that long-term meditation practice is associated with altered resting electroencephalogram patterns, suggestive of long lasting changes in brain activity. We hypothesized that meditation practice might also be associated with changes in the brain's physical structure. Magnetic resonance imaging was used to assess cortical thickness in 20 participants with extensive Insight meditation experience, which involves focused attention to internal experiences. Brain regions associated with attention, interoception and sensory processing were thicker in meditation participants than matched controls, including the prefrontal cortex and right anterior insula. Between-group differences in prefrontal cortical thickness were most pronounced in older participants, suggesting that meditation might offset age-related cortical thinning. Finally, the thickness of two regions correlated with meditation experience. These data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice.

Neuroscientists Olivia Carter and Jack Pettigrew of the University of Queensland, Australia, and colleagues at the University of Queensland and the University of California, Berkeley, reported in the June 7 issue of Current Biology their results from a series of experiments with 76 monks in Ladakh. The goal of their research was to investigate how certain type of meditation can impact conscious visual experience. Researchers found that the skills developed by Tibetan Buddhist monks in their meditation practice strongly influence their experience of binocular rivalry, a perceptual phenomenon that occurs when the brain alternates between viewing different images presented to each eye. The neural processes underlying perceptual rivalry are still unclear but they are thought to be linked with brain mechanisms that regulate attention and conscious awareness.

76 Tibetan Buddhist monks participated in the study. The researchers tested the experience using binocular goggles that prompt visual rivalry. The researchers found that the use of a specific meditation technique, called “one-point meditation” determined a high rate of perceptual dominance. In other words, when they used that technique the normal switching processes of binocular rivalry slowed considerably. This observation suggests that individuals who have trained themselves in meditation techniques can alter the normal fluctuations in the states of their consciousness.

More to explore

Carter, O.L., Presti, D.E., Callistemon, C., Ungerer, Y., Liu, G.B., and Pettigrew, J.D. (2005). Meditation alters perceptual rivalry in Tibetan Buddhist monks. Current Biology, Vol. 15, June 7, 2005, pp. 412-413.