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Nov 17, 2015

The new era of Computational Biomedicine

In recent years, the increasing convergence between nanotechnology, biomedicine and health informatics have generated massive amounts of data, which are changing the way healthcare research, development, and applications are done.

Clinical data integrate physiological data, enabling detailed descriptions of various healthy and diseased states, progression, and responses to therapies. Furthermore, mobile and home-based devices monitor vital signs and activities in real-time and communicate with personal health record services, personal computers, smartphones, caregivers, and health care professionals.

However, our ability to analyze and interpret multiple sources of data lags far behind today’s data generation and storage capacity. Consequently, mathematical and computational models are increasingly used to help interpret massive biomedical data produced by high-throughput genomics and proteomics projects. Advanced applications of computer models that enable the simulation of biological processes are used to generate hypotheses and plan experiments.

The emerging discipline of computational biomedicine is concerned with the application of computer-based techniques and particularly modelling and simulation to human health. Since almost ten years, this vision is at the core of an European-funded program called “Virtual Physiological Human”. The goal of this initiative is to develop next-generation computer technologies to integrate all information available for each patient, and generated computer models capable of predicting how the health of that patient will evolve under certain conditions.

In particular, this programme is expected, over the next decades, to transform the study and practice of healthcare, moving it towards the priorities known as ‘4P's’: predictive, preventative, personalized and participatory medicine. Future developments of computational biomedicine may provide the possibility of developing not just qualitative but truly quantitative analytical tools, that is, models, on the basis of the data available through the system just described. Information not available today (large cohort studies nowadays include thousands of individuals whereas here we are talking about millions of records) will be available for free. Large cohorts of data will be available for online consultation and download. Integrative and multi-scale models will benefit from the availability of this large amount of data by using parameter estimation in a statistically meaningful manner. At the same time distribution maps of important parameters will be generated and continuously updated. Through a certain mechanism, the user will be given the opportunity to express his interest on this or that model so to set up a consensus model selection process. Moreover, models should be open for consultation and annotation. Flexible and user friendly services have many potential positive outcomes. Some examples include simulation of case studies, tests, and validation of specific assumptions on the nature or related diseases, understanding the world-wide distribution of these parameters and disease patterns, ability to hypothesize intervention strategies in cases such as spreading of an infectious disease, and advanced risk modeling.

Apr 05, 2015

Are you concerned about AI?

Recently, a growing number of opinion leaders  have started to point out the potential risks associated to the rapid advancement of Artificial Intelligence. This shared concern has led an interdisciplinary group of scientists, technologists and entrepreneurs to sign an open letter (http://futureoflife.org/misc/open_letter/), drafted by the Future of Life Institute, which focuses on priorities to be considered as Artificial Intelligence develops as well as on the potential dangers posed by this paradigm.

The concern that machines may soon dominate humans, however, is not new: in the last thirty years, this topic has been widely represented in movies (i.e. Terminator, the Matrix), novels and various interactive arts. For example, australian-based performance artist Stelarc has incorporated themes of cyborgization and other human-machine interfaces in his work, by creating a number of installations that confront us with the question of where human ends and technology begins.

Risultati immagini per stelarc

In his 2005 well-received book “The Singularity Is Near: When Humans Transcend Biology” (Viking Penguin: New York), inventor and futurist Ray Kurzweil argued that Artificial Intelligence is one of the interacting forces that, together with genetics, robotic and nanotechnology, may soon converge to overcome our biological limitations and usher in the beginning of the Singularity, during which Kurzweil predicts that human life will be irreversibly transformed. According to Kurzweil, will take place around 2045 and will probably represent the most extraordinary event in all of human history.

Ray Kurzweil’s vision of the future of intelligence is at the forefront of the transhumanist movement, which considers scientific and technological advances as a mean to augment human physical and cognitive abilities, with the final aim of improving and even extending life. According to transhumanists, however, the choice whether to benefit from such enhancement options should generally reside with the individual. The concept of transhumanism has been criticized, among others, by the influential american philosopher of technology, Don Ihde, who pointed out that no technology will ever be completely internalized, since any technological enhancement implies a compromise. Ihde has distinguished four different relations that humans can have with technological artifacts. In particular, in the “embodiment relation” a technology becomes (quasi)transparent, allowing a partial symbiosis of ourself and the technology. In wearing of eyeglasses, as Ihde examplifies, I do not look “at” them but “through” them at the world: they are already assimilated into my body schema, withdrawing from my perceiving.

According to Ihde, there is a doubled desire which arises from such embodiment relations: “It is the doubled desire that, on one side, is a wish for total transparency, total embodiment, for the technology to truly "become me."(...) But that is only one side of the desire. The other side is the desire to have the power, the transformation that the technology makes available. Only by using the technology is my bodily power enhanced and magnified by speed, through distance, or by any of the other ways in which technologies change my capacities. (…) The desire is, at best, contradictory. l want the transformation that the technology allows, but I want it in such a way that I am basically unaware of its presence. I want it in such a way that it becomes me. Such a desire both secretly rejects what technologies are and overlooks the transformational effects which are necessarily tied to human-technology relations. This lllusory desire belongs equally to pro- and anti-technology interpretations of technology.” (Ihde, D. (1990). Technology and the Lifeworld: From Garden to Earth. Bloomington: Indiana, p. 75). 

Despite the different philosophical stances and assumptions on what our future relationship with technology will look like, there is little doubt that these questions will become more pressing and acute in the next years. In my personal view, technology should not be viewed as mean to replace human life, but as an instrument for improving it. As William S. Haney II suggests in his book “Cyberculture, Cyborgs and Science Fiction: Consciousness and the Posthuman” (Rodopi: Amsterdam, 2006), “each person must choose for him or herself between the technological extension of physical experience through mind, body and world on the one hand, and the natural powers of human consciousness on the other as a means to realize their ultimate vision.” (ix, Preface).

Oct 12, 2014

New Material May Help Us To Breathe Underwater

Scientists in Denmark announced they have developed a substance that absorbs, stores and releases huge amounts of oxygen.

The substance is so effective that just a few grains are capable of storing enough oxygen for a single human breath while a bucket full of the new material could capture an entire room of O2.

With the new material there are hopes those requiring medical oxygen might soon be freed from carrying bulky tanks, while SCUBA divers might also be able to use the material to absorb oxygen from water, allowing them to stay submerged for significantly longer.

The substance was developed by tinkering with the molecular structure of cobalt, a chemical element that when found in meteoric iron, resembles a silver-gray metal.
Read More: University of Southern Denmark

Oct 06, 2014

Is the metaverse still alive?

In the last decade, online virtual worlds such as Second Life and alike have become enormously popular. Since their appearance on the technology landscape, many analysts regarded shared 3D virtual spaces as a disruptive innovation, which would have rendered the Web itself obsolete.

This high expectation attracted significant investments from large corporations such as IBM, which started building their virtual spaces and offices in the metaverse. Then, when it became clear that these promises would not be kept, disillusionment set in and virtual worlds started losing their edge. However, this is not a new phenomenon in high-tech, happening over and over again.

The US consulting company Gartner has developed a very popular model to describe this effect, called the “Hype Cycle”. The Hype Cycle provides a graphic representation of the maturity and adoption of technologies and applications.

It consists of five phases, which show how emerging technologies will evolve.

In the first, “technology trigger” phase, a new technology is launched which attracts the interest of media. This is followed by the “peak of inflated expectations”, characterized by a proliferation of positive articles and comments, which generate overexpectations among users and stakeholders.

In the next, “trough of disillusionment” phase, these exaggerated expectations are not fulfilled, resulting in a growing number of negative comments generally followed by a progressive indifference.

In the “slope of enlightenment” the technology potential for further applications becomes more broadly understood and an increasing number of companies start using it.

In the final, “plateau of productivity” stage, the emerging technology established itself as an effective tool and mainstream adoption takes off. 

So what stage in the hype cycle are virtual worlds now?

After the 2006-2007 peak, metaverses entered the downward phase of the hype cycle, progressively loosing media interest, investments and users. Many high-tech analysts still consider this decline an irreversible process.

However, the negative outlook that headed shared virtual worlds into the trough of disillusionment maybe soon reversed. This is thanks to the new interest in virtual reality raised by the Oculus Rift (recently acquired by Facebook for $2 billion), Sony’s Project Morpheus and alike immersive displays, which are still at the takeoff stage in the hype cycle.

Oculus Rift's chief scientist Michael Abrash makes no mystery of the fact that his main ambition has always been to build a metaverse such the one described in Neal Stephenson's (1992) cyberpunk novel Snow Crash. As he writes on the Oculus blog

"Sometime in 1993 or 1994, I read Snow Crash and for the first time thought something like the Metaverse might be possible in my lifetime."

Furthermore, despite the negative comments and deluded expectations, the metaverse keeps attracting new users: in its 10th anniversary on June 23rd 2013, an infographic reported that Second Life had over 1 million users visit around the world monthly, more than 400,000 new accounts per month, and 36 million registered users.

So will Michael Abrash’s metaverse dream come true? Even if one looks into the crystal ball of the hype cycle, the answer is not easily found.

Aug 03, 2014

Fly like a Birdly

Birdly is a full body, fully immersive, Virtual Reality flight simulator developed at the Zurich University of the Arts (ZHdK). With Birdly, you can embody an avian creature, the Red Kite, visualized through Oculus Rift, as it soars over the 3D virtual city of San Francisco, heightened by sonic, olfactory, and wind feedback.

Apr 06, 2014

Glass brain flythrough: beyond neurofeedback

Via Neurogadget

Researchers have developed a new way to explore the human brain in virtual reality. The system, called Glass Brain, which is developed by Philip Rosedale, creator of the famous game Second Life, and Adam Gazzaley, a neuroscientist at the University of California San Francisco, combines brain scanning, brain recording and virtual reality to allow a user to journey through a person’s brain in real-time.

Read the full story on Neurogadget

Feb 16, 2014

How much science is there?

The accelerating pace of scientific publishing and the rise of open access, as depicted by xkcd.com cartoonist Randall Munroe.

Feb 09, 2014

Nick Bostrom: The intelligence explosion hypothesis


Philosopher Nick Bostrom is a Swedish at the University of Oxford known for his work on existential risk and the anthropic principle covered in books such as Global Catastrophic Risks, Anthropic Bias and Human Enhancement. He holds a PhD from the London School of Economics . He is currently the director of both The Future of Humanity Institute and the Programme on the Impacts of Future Technology as part of the Oxford Martin School at Oxford University.

Dec 22, 2013


Researchers at the Institute for Dynamic Systems and Control, ETH Zurich, Switzerland developed a small cube (cm 15X15X15) that can jump up and balance on its corner. Reaction wheels mounted on three faces of the cube rotate at high angular velocities and then brake suddenly, causing the Cubli to jump up. Once the Cubli has almost reached the corner stand up position, controlled motor torques are applied to make it balance on its corner. In addition to balancing, the motor torques can also be used to achieve a controlled fall such that the Cubli can be commanded to fall in any arbitrary direction. Combining these three abilities - jumping up, balancing, and controlled falling - the Cubli is able to 'walk'.

20:59 Posted in Blue sky | Permalink | Comments (0)

Oct 31, 2013

Daniel Dennett – If Brains Are Computers, What Kind Of Computers Are They?

Source: Future of Humanity Institute

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Jul 23, 2013

Augmented Reality - Projection Mapping

Augmented Reality - Projection Mapping from Dane Luttik on Vimeo.

The beginning of infinity

A little old video but still inspiring...

THE BEGINNING OF INFINITY from Jason Silva on Vimeo.

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Aug 04, 2012

Is Little Printer the next (little) thing?

Yes! Definitely yes!

Little Printer lives in your home, bringing you news, puzzles and gossip from your friends. Use your smartphone to set up subscriptions and Little Printer will gather them together to create a timely, beautiful mini-newspaper.

For more see:


19:34 Posted in Blue sky | Permalink | Comments (0)

The Virtual Brain

The Virtual Brain project promises "to deliver the first open simulation of the human brain based on individual large-scale connectivity", by "employing novel concepts from neuroscience, effectively reducing the complexity of the brain simulation while still keeping it sufficiently realistic".

The Virtual Brain team includes well-recognized neuroscientists from all over the world. In the video below, Dr. Randy McIntosh explains what the project is about.

First teaser release of The Virtual Brain software suite is available for download – for Windows, Mac and Linux: http://thevirtualbrain.org/

Mar 31, 2012

Hyper(reality) - The Last Tuesday Society

Project's description: Embodying the concept theorized by hyperrealism theories, the helmet provides a digital experience, immersing the user in an alternative version of reality seen through the helmet. Instead of having a static point of view, the user becomes able to navigate through the 3D environment enabling new behaviours specific to the hyperreal world while still having to physically interact with the real environment. Thus it creates an odd interface between these two states.

Hyper(reality) - The Last Tuesday Society from Maxence

The suit is composed of an helmet with high definition video glasses, an arduino glove with force sensors controlling the 3D view and a harness for the kinect. Each user experience is recorded and analysed, portraiting user behaviours during the experience. Immersed into this dream-like virtual space, the user gradually discovers the collection of curiosities. Behaviours are being modified, the notion of scale is being distorted, all this pushing the boundaries of the physical space. Venitian masks, stuffed animals and old scultpures start floating in the air around the user creating a new sensorial experience.

OutRun: Augmented Reality Driving Video Game

Mar 11, 2012

Augmenting cognition: old concept, new tools

The increasing miniaturization and computing power of information technology devices allow new ways of interaction between human brains and computers, progressively blurring the boundaries between man and machine. An example is provided by brain-computer interface systems, which allow users to use their brain to control the behavior of a computer or of an external device such as a robotic arm (in this latter case, we speak of “neuroprostetics”).


The idea of using information technologies to augment cognition, however, is not new, dating back in 1950’s and 1960’s. One of the first to write about this concept was british psychiatrist William Ross Ashby.

In his Introduction to Cybernetics (1956), he described intelligence as the “power of appropriate selection,” which could be amplified by means of technologies in the same way that physical power is amplified. A second major conceptual contribution towards the development of cognitive augmentation was provided few years later by computer scientist and Internet pioneer Joseph Licklider, in a paper entitled Man-Computer Symbiosis (1960).

In this article, Licklider envisions the development of computer technologies that will enable users “to think in interaction with a computer in the same way that you think with a colleague whose competence supplements your own.” According to his vision, the raise of computer networks would allow to connect together millions of human minds, within a “'thinking center' that will incorporate the functions of present-day libraries together with anticipated advances in information storage and retrieval.” This view represent a departure from the prevailing Artificial Intelligence approach of that time: instead of creating an artificial brain, Licklider focused on the possibility of developing new forms of interaction between human and information technologies, with the aim of extending human intelligence.

A similar view was proposed in the same years by another computer visionnaire, Douglas Engelbart, in its famous 1962 article entitled Augmenting Human Intellect: A Conceptual Framework.

In this report, Engelbart defines the goal of intelligence augmentation as “increasing the capability of a man to approach a complex problem situation, to gain comprehension to suit his particular needs, and to derive solutions to problems. Increased capability in this respect is taken to mean a mixture of the following: more-rapid comprehension, better comprehension, the possibility of gaining a useful degree of comprehension in a situation that previously was too complex, speedier solutions, better solutions, and the possibility of finding solutions to problems that before seemed insoluble (…) We do not speak of isolated clever tricks that help in particular situations.We refer to away of life in an integrated domain where hunches, cut-and-try, intangibles, and the human ‘feel for a situation’ usefully co-exist with powerful concepts, streamlined terminology and notation, sophisticated methods, and high-powered electronic aids.”

These “electronic aids” nowdays include any kind of harware and software computing devices used i.e. to store information in external memories, to process complex data, to perform routine tasks and to support decision making. However, today the concept of cognitive augmentation is not limited to the amplification of human intellectual abilities through external hardware. As recently noted by Nick Bostrom and Anders Sandberg (Sci Eng Ethics 15:311–341, 2009), “What is new is the growing interest in creating intimate links between the external systems and the human user through better interaction. The software becomes less an external tool and more of a mediating ‘‘exoself’’. This can be achieved through mediation, embedding the human within an augmenting ‘‘shell’’ such as wearable computers (…) or virtual reality, or through smart environments in which objects are given extended capabilities” (p. 320).

At the forefront of this trend is neurotechnology, an emerging research and development field which includes technologies that are specifically designed with the aim of improving brain function. Examples of neurotechnologies include brain training games such as BrainAge and programs like Fast ForWord, but also neurodevices used to monitor or regulate brain activity, such as deep brain stimulators (DBS), and smart prosthetics for the replacement of impaired sensory systems (i.e. cochlear or retinal implants).

Clearly, the vision of neurotechnology is not free of issues. The more they become powerful and sophisticated, the more attention should be dedicated to understand the socio-economic, legal and ethical implications of their applications in various field, from medicine to neuromarketing.


Jan 27, 2012

Positive Technology: Using Interactive Technologies to Promote Positive Functioning

Positive Technology: Using Interactive Technologies to Promote Positive Functioning

G. Riva, R.M. Baños, C. Botella, B.K. Wiederhold, A. Gaggioli

Cyberpsychology, Behavior, and Social Networking (Online Ahead of Print: December 9, 2011) DOI

Abstract. It is generally assumed that technology assists individuals in improving the quality of their lives. However, the impact of new technologies and media on well-being and positive functioning is still somewhat controversial. In this paper, we contend that the quality of experience should become the guiding principle in the design and development of new technologies, as well as a primary metric for the evaluation of their applications. The emerging discipline of Positive Psychology provides a useful framework to address this challenge. Positive Psychology is the scientific study of optimal human functioning and flourishing. Instead of drawing on a “disease model” of human behavior, it focuses on factors that enable individuals and communities to thrive and build the best in life. In this paper, we propose the “Positive Technology” approach—the scientific and applied approach to the use of technology for improving the quality of our personal experience through its structuring, augmentation, and/or replacement—as a way of framing a suitable object of study in the field of cyberpsychology and human–computer interaction. Specifically, we suggest that it is possible to use technology to influence three specific features of our experience—affective quality, engagement/actualization, and connectedness—that serve to promote adaptive behaviors and positive functioning. In this framework, positive technologies are classified according to their effects on a specific feature of personal experience. Moreover, for each level, we have identified critical variables that can be manipulated to guide the design and development of positive technologies.

Dec 31, 2011

10 videos on our near future

Happy New Year to all PT readers! - Andrea Gaggioli

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Nov 26, 2011

Curiosity (did not) kill the cat

Today at 10:02 am the latest Mars Rover, Curiosity was launched into the deep space. The $2.5 billion exploratory system started its eight month journey to Mars where it will spend another two years researching the conditions for (past or future) life. The nuclear-powered Curiosity is much larger than any previous Mars Rover and five times heavier. Its equipment includes a drill on a 2.1-meter arm and a laser to vaporize rocks for easier onboard analysis.

When I first watched this video this morning I was really amazed by the technology, the landing strategy and the terrific level of sophistication of the rover system. Then I thought to myself - if there is enough brainpower on earth to make this vision a reality, then it must be also possible to workout a solution for the global economy!

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